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Reviewed May 2011
What is the official name of the FREM1 gene?
The official name of this gene is “FRAS1 related extracellular matrix 1.”
FREM1 is the gene's official symbol. The FREM1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FREM1 gene?
The FREM1 gene provides instructions for making a protein that is involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues.
The FREM1 protein is one of a group of proteins, including proteins called FRAS1 and FREM2, that interact during embryonic development as components of basement membranes. Basement membranes help anchor layers of cells lining the surfaces and cavities of the body (epithelial cells) to other embryonic tissues, including those that give rise to connective tissues (such as skin and cartilage) and the kidneys.
How are changes in the FREM1 gene related to health conditions?
Where is the FREM1 gene located?
Cytogenetic Location: 9p22.3
Molecular Location on chromosome 9: base pairs 14,734,666 to 14,911,647
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The FREM1 gene is located on the short (p) arm of chromosome 9 at position 22.3.
More precisely, the FREM1 gene is located from base pair 14,734,666 to base pair 14,911,647 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FREM1?
You and your healthcare professional may find the following resources about FREM1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FREM1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FREM1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.