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The information on this page was automatically extracted from online scientific databases.

What is the official name of the FMO5 gene?

The official name of this gene is “flavin containing monooxygenase 5.”

FMO5 is the gene's official symbol. The FMO5 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the FMO5 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

From UniProtThis link leads to a site outside Genetics Home Reference.:

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

How are changes in the FMO5 gene related to health conditions?

Genetics Home Reference provides information about 1q21.1 microdeletion, which is associated with changes in the FMO5 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the FMO5 gene and its association with health conditions.

Where is the FMO5 gene located?

Cytogenetic Location: 1q21.1

Molecular Location on chromosome 1: base pairs 147,184,299 to 147,225,797

The FMO5 gene is located on the long (q) arm of chromosome 1 at position 21.1.

The FMO5 gene is located on the long (q) arm of chromosome 1 at position 21.1.

More precisely, the FMO5 gene is located from base pair 147,184,299 to base pair 147,225,797 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about FMO5?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding FMO5?

alternative splicing ; enzyme ; inherited ; oxidation ; polymorphism ; splicing ; syndrome ; transcript ; trimethylamine ; xenobiotics

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: September 28, 2015