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Reviewed April 2013
What is the official name of the FLT4 gene?
The official name of this gene is “fms-related tyrosine kinase 4.”
FLT4 is the gene's official symbol. The FLT4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FLT4 gene?
The FLT4 gene provides instructions for making a protein called vascular endothelial growth factor receptor 3 (VEGFR-3), which regulates the development and maintenance of the lymphatic system. The lymphatic system produces and transports fluids and immune cells throughout the body. VEGFR-3 is turned on (activated) by two proteins called vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D). When VEGF-C and VEGF-D attach (bind) to VEGFR-3, chemical signals are produced that regulate the growth, movement, and survival of lymphatic cells.
Does the FLT4 gene share characteristics with other genes?
The FLT4 gene belongs to a family of genes called immunoglobulin superfamily, immunoglobulin-like domain containing (immunoglobulin superfamily, immunoglobulin-like domain containing). It also belongs to a family of genes called immunoglobulin superfamily, I-set domain containing (immunoglobulin superfamily, I-set domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the FLT4 gene related to health conditions?
Where is the FLT4 gene located?
Cytogenetic Location: 5q35.3
Molecular Location on chromosome 5: base pairs 180,601,506 to 180,650,271
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The FLT4 gene is located on the long (q) arm of chromosome 5 at position 35.3.
More precisely, the FLT4 gene is located from base pair 180,601,506 to base pair 180,650,271 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FLT4?
You and your healthcare professional may find the following resources about FLT4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FLT4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FLT4?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.