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Reviewed November 2013
What is the official name of the FKBP10 gene?
The official name of this gene is “FK506 binding protein 10, 65 kDa.”
FKBP10 is the gene's official symbol. The FKBP10 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FKBP10 gene?
The FKBP10 gene provides instructions for making a protein called FK506-binding protein 65 (FKBP65). This protein is found in a cell structure called the endoplasmic reticulum, which is involved in protein production, processing, and transport. FKBP65 is important for the correct processing of complex molecules called collagen and elastin, which are part of the intricate lattice of proteins and other molecules that forms in the spaces between cells (the extracellular matrix). This matrix provides structure and strength to connective tissues that support the body's joints and organs.
In the extracellular matrix, collagen molecules are cross-linked to one another to form long, thin fibrils. The formation of cross-links results in very strong collagen fibrils. The FKBP65 protein attaches to collagen molecules and plays a role in their cross-linking. It is thought to be involved in a reaction called hydroxylation that modifies a particular region of the collagen molecule and is necessary for cross-linking of the molecules.
The FKBP65 protein is also involved in the formation of elastin. In particular, FKBP65 helps with the proper folding of a protein called tropoelastin. Multiple copies of tropoelastin attach to one another to make elastin. Elastin is the major component of elastic fibers, which provide strength and elasticity to connective tissues as part of the extracellular matrix.
Does the FKBP10 gene share characteristics with other genes?
The FKBP10 gene belongs to a family of genes called EF-hand domain containing (EF-hand domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the FKBP10 gene related to health conditions?
Where is the FKBP10 gene located?
Cytogenetic Location: 17q21.2
Molecular Location on chromosome 17: base pairs 41,812,261 to 41,823,216
The FKBP10 gene is located on the long (q) arm of chromosome 17 at position 21.2.
More precisely, the FKBP10 gene is located from base pair 41,812,261 to base pair 41,823,216 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FKBP10?
You and your healthcare professional may find the following resources about FKBP10 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FKBP10 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FKBP10?
amino acid ; cell ; chaperone ; collagen ; connective tissue ; elastic ; endoplasmic reticulum ; extracellular ; extracellular matrix ; gene ; joint ; molecule ; mutation ; osteogenesis ; population ; precursor ; protein ; syndrome ; tissue ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.