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Reviewed February 2012
What is the official name of the FIP1L1 gene?
The official name of this gene is “FIP1 like 1 (S. cerevisiae).”
FIP1L1 is the gene's official symbol. The FIP1L1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FIP1L1 gene?
The FIP1L1 gene provides instructions for making part of a protein complex named cleavage and polyadenylation specificity factor (CPSF). This complex of proteins plays an important role in processing molecules called messenger RNAs (mRNAs), which serve as the genetic blueprints for making proteins. The CPSF protein complex helps add a string of the RNA building block adenine to the mRNA, creating a polyadenine tail or poly(A) tail. The poly(A) tail is important for stability of the mRNA and for protein production from the blueprint.
How are changes in the FIP1L1 gene related to health conditions?
Where is the FIP1L1 gene located?
Cytogenetic Location: 4q12
Molecular Location on chromosome 4: base pairs 53,377,646 to 53,462,611
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The FIP1L1 gene is located on the long (q) arm of chromosome 4 at position 12.
More precisely, the FIP1L1 gene is located from base pair 53,377,646 to base pair 53,462,611 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FIP1L1?
You and your healthcare professional may find the following resources about FIP1L1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FIP1L1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FIP1L1?
adenine ; biomarker ; cancer ; cell ; chromosome ; chronic ; deletion ; eosinophils ; fusion gene ; gene ; leukemia ; mRNA ; mutation ; pharmacogenetics ; polyadenylation ; proliferate ; proliferation ; protein ; RNA ; somatic mutation ; specificity
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.