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Reviewed April 2008
What is the official name of the FH gene?
The official name of this gene is “fumarate hydratase.”
FH is the gene's official symbol. The FH gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FH gene?
The FH gene provides instructions for making an enzyme called fumarase (also known as fumarate hydratase). Fumarase participates in an important series of reactions known as the citric acid cycle or Krebs cycle, which allows cells to use oxygen and generate energy. Specifically, fumarase helps convert a molecule called fumarate to a molecule called malate.
How are changes in the FH gene related to health conditions?
Genetics Home Reference provides information about primary macronodular adrenal hyperplasia, which is also associated with changes in the FH gene.
Where is the FH gene located?
Cytogenetic Location: 1q42.1
Molecular Location on chromosome 1: base pairs 241,497,557 to 241,519,785
The FH gene is located on the long (q) arm of chromosome 1 at position 42.1.
More precisely, the FH gene is located from base pair 241,497,557 to base pair 241,519,785 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FH?
You and your healthcare professional may find the following resources about FH helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FH gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FH?
amino acid ; cancer ; cell ; cell division ; chronic ; deficiency ; DNA ; enzyme ; gene ; hereditary ; hyperplasia ; hypoxia ; inherit ; inherited ; molecule ; oxygen ; oxygen deficiency ; protein ; radiation ; renal ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.