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Reviewed February 2012
What is the official name of the FGG gene?
The official name of this gene is “fibrinogen gamma chain.”
FGG is the gene's official symbol. The FGG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FGG gene?
The FGG gene provides instructions for making the fibrinogen gamma (γ) chain, one piece (subunit) of the fibrinogen protein. This protein is important for blood clot formation (coagulation), which is needed to stop excessive bleeding after injury. To form fibrinogen, the γ chain attaches to the fibrinogen A alpha (Aα) and fibrinogen B beta (Bβ) chains, each produced from different genes. Two sets of this three-protein complex combine to form functional fibrinogen.
For coagulation to occur, another protein called thrombin removes a piece from the Aα and the Bβ subunits of the functional fibrinogen protein (the pieces are called the A and B fibrinopeptides). This process converts fibrinogen to fibrin, the main protein in blood clots. Fibrin proteins attach to each other, forming a stable network that makes up the blood clot.
Does the FGG gene share characteristics with other genes?
The FGG gene belongs to a family of genes called endogenous ligands (endogenous ligands).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the FGG gene related to health conditions?
Where is the FGG gene located?
Cytogenetic Location: 4q28
Molecular Location on chromosome 4: base pairs 154,604,134 to 154,612,750
The FGG gene is located on the long (q) arm of chromosome 4 at position 28.
More precisely, the FGG gene is located from base pair 154,604,134 to base pair 154,612,750 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FGG?
You and your healthcare professional may find the following resources about FGG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FGG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FGG?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.