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Reviewed June 2005
What is the official name of the FGFR4 gene?
The official name of this gene is “fibroblast growth factor receptor 4.”
FGFR4 is the gene's official symbol. The FGFR4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FGFR4 gene?
The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.
The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.
Does the FGFR4 gene share characteristics with other genes?
The FGFR4 gene belongs to a family of genes called CD (CD molecules). It also belongs to a family of genes called immunoglobulin superfamily, I-set domain containing (immunoglobulin superfamily, I-set domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the FGFR4 gene related to health conditions?
Where is the FGFR4 gene located?
Cytogenetic Location: 5q35.2
Molecular Location on chromosome 5: base pairs 177,086,904 to 177,098,125
The FGFR4 gene is located on the long (q) arm of chromosome 5 at position 35.2.
More precisely, the FGFR4 gene is located from base pair 177,086,904 to base pair 177,098,125 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FGFR4?
You and your healthcare professional may find the following resources about FGFR4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FGFR4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FGFR4?
acids ; arginine ; cancer ; cell ; cell division ; colon ; cones ; embryo ; fibroblast ; gastric ; gene ; glycine ; growth factor ; kinase ; metastasis ; mutation ; nucleus ; ovarian ; pancreatic ; polymorphism ; progression ; prostate ; protein ; receptor ; retina ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.