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Genetics Home Reference: your guide to understanding genetic conditions
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FEV

The information on this page was automatically extracted from online scientific databases.

What is the official name of the FEV gene?

The official name of this gene is “FEV (ETS oncogene family).”

FEV is the gene's official symbol. The FEV gene is also known by other names, listed below.

What is the normal function of the FEV gene?

From NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/54738):

This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]

From UniProt (http://www.uniprot.org/uniprot/Q99581):

Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

How are changes in the FEV gene related to health conditions?

Genetics Home Reference provides information about Ewing sarcoma, which is associated with changes in the FEV gene.
UniProt (http://www.uniprot.org/uniprot/Q99581) provides the following information about the FEV gene's known or predicted involvement in human disease.

Sudden infant death syndrome (SIDS): SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Disease susceptibility may be associated with variations affecting the gene represented in this entry.

A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

OMIM.org (http://omim.org/), a catalog designed for genetics professionals and researchers, provides the following information about the FEV gene and its association with health conditions.
OMIM
Number
Title

Where is the FEV gene located?

Cytogenetic Location: 2q36

Molecular Location on chromosome 2: base pairs 218,981,086 to 218,985,656

The FEV gene is located on the long (q) arm of chromosome 2 at position 36.

The FEV gene is located on the long (q) arm of chromosome 2 at position 36.

More precisely, the FEV gene is located from base pair 218,981,086 to base pair 218,985,656 on chromosome 2.

See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.

Where can I find additional information about FEV?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the FEV gene or gene products?

  • HSRNAFEV
  • PET-1

See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What glossary definitions help with understanding FEV?

alanine ; amino acid ; anxiety ; cardiac ; cell ; chromosome ; depression ; differentiation ; DNA ; domain ; dysrhythmias ; expressed ; gene ; HT ; inborn errors of metabolism ; metabolism ; pathogenic ; protein ; repressor ; respiratory ; sarcoma ; susceptibility ; syndrome ; transcription ; transcription factor ; translocation

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Published: February 23, 2015