|http://ghr.nlm.nih.gov/ A service of the U.S. National Library of Medicine®|
The official name of this gene is “FEV (ETS oncogene family).”
FEV is the gene's official symbol. The FEV gene is also known by other names, listed below.
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
Sudden infant death syndrome (SIDS): SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Disease susceptibility may be associated with variations affecting the gene represented in this entry.
A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.
|272120 (http://omim.org/entry/272120)||SUDDEN INFANT DEATH SYNDROME|
|607150 (http://omim.org/entry/607150)||FIFTH EWING SARCOMA VARIANT|
Cytogenetic Location: 2q36
Molecular Location on chromosome 2: base pairs 218,981,086 to 218,985,656
The FEV gene is located on the long (q) arm of chromosome 2 at position 36.
More precisely, the FEV gene is located from base pair 218,981,086 to base pair 218,985,656 on chromosome 2.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
alanine ; amino acid ; anxiety ; cardiac ; cell ; chromosome ; depression ; differentiation ; DNA ; domain ; dysrhythmias ; expressed ; gene ; HT ; inborn errors of metabolism ; metabolism ; pathogenic ; protein ; repressor ; respiratory ; sarcoma ; susceptibility ; syndrome ; transcription ; transcription factor ; translocation
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.