What is the official name of the FCGR2B gene?
The official name of this gene is “Fc fragment of IgG, low affinity IIb, receptor (CD32).”
FCGR2B is the gene's official symbol. The FCGR2B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FCGR2B gene?
- From NCBI Gene:
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
- From UniProt (FCG2B_HUMAN):
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
NOTE: UniProt (FCG2B_HUMAN) suggests using caution when interpreting this information.
- From UniProt (FCG2C_HUMAN):
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
NOTE: UniProt (FCG2C_HUMAN) suggests using caution when interpreting this information.
How are changes in the FCGR2B gene related to health conditions?
- Genetics Home Reference provides information about these conditions associated with changes in the FCGR2B gene:
- UniProt (FCG2B_HUMAN) provides the following information about the FCGR2B gene's known or predicted involvement in human disease.
A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
Systemic lupus erythematosus (SLE): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variations affecting the gene represented in this entry.
- NCBI Gene lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the FCGR2B gene.
- Susceptibility to malaria
- Systemic lupus erythematosus
- OMIM.org, a catalog designed for genetics professionals and researchers, provides the following information about the FCGR2B gene and its association with health conditions.
Where is the FCGR2B gene located?
Cytogenetic Location: 1q23
Molecular Location on chromosome 1: base pairs 161,663,115 to 161,678,654
The FCGR2B gene is located on the long (q) arm of chromosome 1 at position 23.
More precisely, the FCGR2B gene is located from base pair 161,663,115 to base pair 161,678,654 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FCGR2B?
You and your healthcare professional may find the following resources about FCGR2B helpful.
- Genetic Testing Registry - Repository of genetic test information
You may also be interested in these resources, which are designed for genetics professionals and researchers.
- OMIM - Genetic disorder catalog
- Research Resources - Tools for researchers
What other names do people use for the FCGR2B gene or gene products?
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FCGR2B?
The resources on this site should not be used as a substitute for
professional medical care or advice. Users seeking information about
a personal genetic disease, syndrome, or condition should consult with a qualified
See How can I find a genetics professional in my area? in the Handbook.