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Reviewed July 2014
What is the official name of the FAT4 gene?
The official name of this gene is “FAT atypical cadherin 4.”
FAT4 is the gene's official symbol. The FAT4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FAT4 gene?
The FAT4 gene provides instructions for making a protein that is found in most tissues. The protein spans the membrane surrounding cells so that part of the protein is outside the cell and part of the protein is inside the cell. The precise function of the FAT4 protein is largely unknown; however, research shows that the FAT4 protein is likely involved in determining the position of various components within cells (cell polarity). The FAT4 protein is also thought to function as a tumor suppressor, which means that it keeps cells from growing and dividing too rapidly or in an uncontrolled way.
Does the FAT4 gene share characteristics with other genes?
The FAT4 gene belongs to a family of genes called CDH (cadherins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the FAT4 gene related to health conditions?
Where is the FAT4 gene located?
Cytogenetic Location: 4q28.1
Molecular Location on chromosome 4: base pairs 125,315,897 to 125,492,932
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The FAT4 gene is located on the long (q) arm of chromosome 4 at position 28.1.
More precisely, the FAT4 gene is located from base pair 125,315,897 to base pair 125,492,932 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FAT4?
You and your healthcare professional may find the following resources about FAT4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FAT4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FAT4?
amino acid ; atypical ; cancer ; carcinoma ; cell ; disability ; gastric ; gene ; glutamic acid ; hepatocellular carcinoma ; inherited ; liver cancer ; lymph ; lymphatic system ; lymphedema ; lysine ; malformation ; melanoma ; mutation ; pancreatic ; protein ; rupture ; stomach ; syndrome ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.