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Reviewed May 2010
What is the official name of the F8 gene?
The official name of this gene is “coagulation factor VIII.”
F8 is the gene's official symbol. The F8 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the F8 gene?
The F8 gene provides instructions for making a protein called coagulation factor VIII. Coagulation factors are a group of related proteins that are essential for the formation of blood clots. After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss.
Coagulation factor VIII is made chiefly by cells in the liver. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.
How are changes in the F8 gene related to health conditions?
Where is the F8 gene located?
Cytogenetic Location: Xq28
Molecular Location on the X chromosome: base pairs 154,835,788 to 155,026,934
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The F8 gene is located on the long (q) arm of the X chromosome at position 28.
More precisely, the F8 gene is located from base pair 154,835,788 to base pair 155,026,934 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about F8?
You and your healthcare professional may find the following resources about F8 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the F8 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding F8?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.