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Reviewed May 2013
What is the official name of the F5 gene?
The official name of this gene is “coagulation factor V (proaccelerin, labile factor).”
F5 is the gene's official symbol. The F5 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the F5 gene?
The F5 gene provides instructions for making a protein called coagulation factor V. Coagulation factors are a group of related proteins that make up the coagulation system, a series of chemical reactions that form blood clots. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair.
The factor V protein is made primarily by cells in the liver. The protein circulates in the bloodstream in an inactive form until the coagulation system is activated by an injury that damages blood vessels. When coagulation factor V is activated, it interacts with coagulation factor X. The active forms of these two coagulation factors (written as factor Va and factor Xa, respectively) form a complex that converts an important coagulation protein called prothrombin to its active form, thrombin. Thrombin then converts a protein called fibrinogen into fibrin, which is the material that forms the clot.
Coagulation factor V has another role in regulating the coagulation system through its interaction with activated protein C (APC). APC normally inactivates coagulation factor V by cutting (cleaving) it at specific sites. This inactivation slows down the clotting process and prevents clots from growing too large. When coagulation factor V is cleaved at a particular site (protein position 506), it can work with APC to inactivate factor VIIIa, which is another protein that is essential for normal blood clotting.
How are changes in the F5 gene related to health conditions?
Where is the F5 gene located?
Cytogenetic Location: 1q23
Molecular Location on chromosome 1: base pairs 169,511,954 to 169,586,531
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The F5 gene is located on the long (q) arm of chromosome 1 at position 23.
More precisely, the F5 gene is located from base pair 169,511,954 to base pair 169,586,531 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about F5?
You and your healthcare professional may find the following resources about F5 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the F5 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding F5?
amino acid ; arginine ; ascites ; biomarker ; blood clotting ; blood coagulation ; blood coagulation factor ; cell ; clotting ; coagulation ; coagulation factors ; deficiency ; factor V deficiency ; fibrin ; fibrinogen ; gene ; glutamine ; injury ; mutation ; parahemophilia ; pharmacogenetics ; protein ; syndrome ; thrombin ; thrombophilia
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (16 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.