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Reviewed April 2009
What is the official name of the F12 gene?
The official name of this gene is “coagulation factor XII.”
F12 is the gene's official symbol. The F12 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the F12 gene?
The F12 gene provides instructions for making a protein called coagulation factor XII. Coagulation factors are a group of related proteins that are essential for normal blood clotting (coagulation). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Factor XII circulates in the bloodstream in an inactive form until it is activated, usually by coming in contact with damaged blood vessel walls. Upon activation, factor XII interacts with coagulation factor XI. This interaction sets off a chain of additional chemical reactions that form a blood clot.
Factor XII also plays a role in stimulating inflammation, a normal body response to infection, irritation, or other injury. When factor XII is activated, it also interacts with a protein called plasma prekallikrein. This interaction initiates a series of chemical reactions that lead to the release of a protein called bradykinin. Bradykinin promotes inflammation by increasing the permeability of blood vessel walls, allowing more fluids to leak into body tissues. This leakage causes the swelling that accompanies inflammation.
How are changes in the F12 gene related to health conditions?
Where is the F12 gene located?
Cytogenetic Location: 5q35.3
Molecular Location on chromosome 5: base pairs 177,402,138 to 177,416,524
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The F12 gene is located on the long (q) arm of chromosome 5 at position 35.3.
More precisely, the F12 gene is located from base pair 177,402,138 to base pair 177,416,524 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about F12?
You and your healthcare professional may find the following resources about F12 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the F12 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding F12?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)