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Reviewed January 2014
What is the official name of the EOGT gene?
The official name of this gene is “EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase.”
EOGT is the gene's official symbol. The EOGT gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the EOGT gene?
The EOGT gene provides instructions for making a protein that modifies certain other proteins by transferring a molecule called N-acetylglucosamine to them. This change, called an O-GlcNAc modification, can affect protein stability and regulate several cellular processes, such as signaling in cells and the first step in the production of proteins from genes (transcription). Little is known about the proteins altered by the EOGT protein or what effect the O-GlcNAc modification has on them. Studies suggest that Notch proteins may be modified by EOGT. Notch proteins stimulate signaling pathways important during the development of several tissues throughout the body, including the bones, heart, liver, muscles, and blood cells, among others.
How are changes in the EOGT gene related to health conditions?
Where is the EOGT gene located?
Cytogenetic Location: 3p14.1
Molecular Location on chromosome 3: base pairs 68,975,211 to 69,013,960
The EOGT gene is located on the short (p) arm of chromosome 3 at position 14.1.
More precisely, the EOGT gene is located from base pair 68,975,211 to base pair 69,013,960 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about EOGT?
You and your healthcare professional may find the following resources about EOGT helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the EOGT gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding EOGT?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.