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Reviewed January 2012
What is the official name of the ELANE gene?
The official name of this gene is “elastase, neutrophil expressed.”
ELANE is the gene's official symbol. The ELANE gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ELANE gene?
The ELANE gene provides instructions for making a protein called neutrophil elastase. This protein is found in neutrophils, a type of white blood cell that plays a role in inflammation and in fighting infection. When the body starts an immune response to fight an infection, neutrophils release neutrophil elastase. This protein then modifies the function of certain cells and proteins to fight the infection.
How are changes in the ELANE gene related to health conditions?
Where is the ELANE gene located?
Cytogenetic Location: 19p13.3
Molecular Location on chromosome 19: base pairs 850,988 to 856,245
The ELANE gene is located on the short (p) arm of chromosome 19 at position 13.3.
More precisely, the ELANE gene is located from base pair 850,988 to base pair 856,245 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ELANE?
You and your healthcare professional may find the following resources about ELANE helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ELANE gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ELANE?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.