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Reviewed January 2010
What is the official name of the EGR2 gene?
The official name of this gene is “early growth response 2.”
EGR2 is the gene's official symbol. The EGR2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the EGR2 gene?
The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are called transcription factors.
The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the protective substance that covers nerve cells. Myelin is essential for the efficient transmission of nerve impulses.
How are changes in the EGR2 gene related to health conditions?
Where is the EGR2 gene located?
Cytogenetic Location: 10q21.1
Molecular Location on chromosome 10: base pairs 62,811,996 to 62,919,895
The EGR2 gene is located on the long (q) arm of chromosome 10 at position 21.1.
More precisely, the EGR2 gene is located from base pair 62,811,996 to base pair 62,919,895 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about EGR2?
You and your healthcare professional may find the following resources about EGR2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the EGR2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding EGR2?
acids ; amino acid ; arginine ; aspartic acid ; congenital ; demyelination ; DNA ; gene ; histidine ; mutation ; neuropathy ; peripheral ; peripheral nerves ; protein ; sensory cells ; syndrome ; transcription ; tryptophan ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.