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Reviewed October 2015
What is the official name of the EGFR gene?
The official name of this gene is “epidermal growth factor receptor.”
EGFR is the gene's official symbol. The EGFR gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the EGFR gene?
The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning allows the receptor to attach (bind) to other proteins, called ligands, outside the cell and to receive signals that help the cell respond to its environment. Ligands and receptors fit together like keys into locks. Epidermal growth factor receptor binds to at least seven different ligands. The binding of a ligand to an epidermal growth factor receptor allows the receptor to attach to a nearby receptor protein (dimerize), turning on (activating) the receptor complex. As a result, signaling pathways within the cell are triggered that promote cell growth and division (proliferation) and cell survival.
How are changes in the EGFR gene related to health conditions?
Where is the EGFR gene located?
Cytogenetic Location: 7p12
Molecular Location on chromosome 7: base pairs 55,019,031 to 55,207,337
The EGFR gene is located on the short (p) arm of chromosome 7 at position 12.
More precisely, the EGFR gene is located from base pair 55,019,031 to base pair 55,207,337 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about EGFR?
You and your healthcare professional may find the following resources about EGFR helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the EGFR gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding EGFR?
adenocarcinoma ; cancer ; cell ; cell membrane ; cell proliferation ; DNA ; exon ; gene ; growth factor ; kinase ; ligand ; oncogene ; personalized medicine ; pharmacogenetics ; pharmacogenomics ; proliferate ; proliferation ; protein ; proto-oncogene ; receptor ; tumor ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.