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Reviewed August 2006
What is the official name of the EDARADD gene?
The official name of this gene is “EDAR-associated death domain.”
EDARADD is the gene's official symbol. The EDARADD gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the EDARADD gene?
The EDARADD gene provides instructions for making a protein called the EDAR-associated death domain protein. This protein is part of a signaling pathway that plays an important role in development before birth. Specifically, it is critical for interactions between two embryonic cell layers called the ectoderm and the mesoderm. In the early embryo, these cell layers form the basis for many of the body's organs and tissues. Ectoderm-mesoderm interactions are essential for the formation of several structures that arise from the ectoderm, including the skin, hair, nails, teeth, and sweat glands.
The EDARADD protein interacts with another protein, called the ectodysplasin A receptor, which is produced from the EDAR gene. This interaction occurs at a region called the death domain that is present in both proteins. The EDARADD protein acts as an adapter, which means it assists the ectodysplasin A receptor in triggering chemical signals within cells. These signals affect cell activities such as division, growth, and maturation. Before birth, this signaling pathway controls the formation of ectodermal structures such as hair follicles, sweat glands, and teeth.
How are changes in the EDARADD gene related to health conditions?
Where is the EDARADD gene located?
Cytogenetic Location: 1q42.3
Molecular Location on chromosome 1: base pairs 236,394,379 to 236,484,707
The EDARADD gene is located on the long (q) arm of chromosome 1 at position 42.3.
More precisely, the EDARADD gene is located from base pair 236,394,379 to base pair 236,484,707 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about EDARADD?
You and your healthcare professional may find the following resources about EDARADD helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the EDARADD gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding EDARADD?
amino acid ; autosomal ; autosomal recessive ; cell ; domain ; dysplasia ; ectoderm ; embryo ; embryonic ; gene ; glutamine ; inheritance ; kb ; lysine ; mesoderm ; mutation ; protein ; receptor ; recessive
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.