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Reviewed September 2015
What is the official name of the DUOX2 gene?
The official name of this gene is “dual oxidase 2.”
DUOX2 is the gene's official symbol. The DUOX2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DUOX2 gene?
The DUOX2 gene provides instructions for making an enzyme called dual oxidase 2. This enzyme is found in the thyroid gland, which is a butterfly-shaped tissue in the lower neck. The enzyme is also found in salivary glands, the digestive tract, and airways in the throat and lungs. Dual oxidase 2 helps generate a chemical called hydrogen peroxide. In the thyroid, hydrogen peroxide is required for one of the final steps in the production of thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
Does the DUOX2 gene share characteristics with other genes?
The DUOX2 gene belongs to a family of genes called EF-hand domain containing (EF-hand domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the DUOX2 gene related to health conditions?
Where is the DUOX2 gene located?
Cytogenetic Location: 15q15.3
Molecular Location on chromosome 15: base pairs 45,092,653 to 45,114,161
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The DUOX2 gene is located on the long (q) arm of chromosome 15 at position 15.3.
More precisely, the DUOX2 gene is located from base pair 45,092,653 to base pair 45,114,161 on chromosome 15.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DUOX2?
You and your healthcare professional may find the following resources about DUOX2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DUOX2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DUOX2?
acids ; adenine ; cell ; congenital ; digestive ; enzyme ; gene ; goiter ; hormone ; hydrogen peroxide ; hypothyroidism ; metabolism ; mutation ; oxidase ; phosphate ; synthesis ; thyroid ; thyroid hormones ; tissue ; transient
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.