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Genetics Home Reference: your guide to understanding genetic conditions     A service of the U.S. National Library of Medicine®


Reviewed January 2014

What is the official name of the DOCK6 gene?

The official name of this gene is “dedicator of cytokinesis 6.”

DOCK6 is the gene's official symbol. The DOCK6 gene is also known by other names, listed below.

What is the normal function of the DOCK6 gene?

The DOCK6 gene provides instructions for making a protein known as a guanine nucleotide exchange factor (GEF). GEFs turn on (activate) proteins called GTPases, which play an important role in chemical signaling within cells. Often referred to as molecular switches, GTPases can be turned on and off. GTPases are turned off (inactivated) when they are attached (bound) to a molecule called GDP and are activated when they are bound to another molecule called GTP. The DOCK6 protein activates GTPases known as Cdc42 and Rac1 by exchanging GTP for the attached GDP. Once Cdc42 and Rac1 are active, they transmit signals that are critical for various aspects of embryonic development. The DOCK6 protein appears to regulate these GTPases specifically during development of the limbs, skull, and heart. DOCK6 also plays a role in the development of fibers (axons) that extend from nerve cells.

How are changes in the DOCK6 gene related to health conditions?

Adams-Oliver syndrome - caused by mutations in the DOCK6 gene

Mutations in the DOCK6 gene cause Adams-Oliver syndrome, a condition characterized by areas of missing skin (aplasia cutis congenita), usually on the scalp, and malformations of the hands and feet. These mutations lead to production of an abnormally short DOCK6 protein that is likely unable to function. The inability of DOCK6 to turn on Cdc42 or Rac1 leads to a reduction in their signaling, which impairs proper development of the skin on the top of the head and the bones in the hands and feet.

Where is the DOCK6 gene located?

Cytogenetic Location: 19p13.2

Molecular Location on chromosome 19: base pairs 11,199,292 to 11,262,500

The DOCK6 gene is located on the short (p) arm of chromosome 19 at position 13.2.

The DOCK6 gene is located on the short (p) arm of chromosome 19 at position 13.2.

More precisely, the DOCK6 gene is located from base pair 11,199,292 to base pair 11,262,500 on chromosome 19.

See How do geneticists indicate the location of a gene? ( in the Handbook.

Where can I find additional information about DOCK6?

You and your healthcare professional may find the following resources about DOCK6 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the DOCK6 gene or gene products?

  • AOS2
  • dedicator of cytokinesis protein 6
  • KIAA1395
  • ZIR1

See How are genetic conditions and genes named? ( in the Handbook.

What glossary definitions help with understanding DOCK6?

axons ; cytokinesis ; embryonic ; gene ; GTP ; guanine ; molecule ; nucleotide ; protein ; syndrome

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.


  • Miyamoto Y, Torii T, Yamamori N, Ogata T, Tanoue A, Yamauchi J. Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. Sci Signal. 2013 Mar 5;6(265):ra15. doi: 10.1126/scisignal.2003661. (
  • Miyamoto Y, Yamauchi J, Sanbe A, Tanoue A. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Exp Cell Res. 2007 Feb 15;313(4):791-804. Epub 2006 Dec 6. (
  • NCBI Gene (
  • Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol. 2004 Jan 1;265(1):23-32. Review. (
  • Shaheen R, Faqeih E, Sunker A, Morsy H, Al-Sheddi T, Shamseldin HE, Adly N, Hashem M, Alkuraya FS. Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Am J Hum Genet. 2011 Aug 12;89(2):328-33. doi: 10.1016/j.ajhg.2011.07.009. Epub 2011 Aug 4. (


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? ( in the Handbook.

Reviewed: January 2014
Published: October 5, 2015