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Reviewed November 2012
What is the official name of the DNMT1 gene?
The official name of this gene is “DNA (cytosine-5-)-methyltransferase 1.”
DNMT1 is the gene's official symbol. The DNMT1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DNMT1 gene?
The DNMT1 gene provides instructions for making an enzyme called DNA (cytosine-5)-methyltransferase 1. This enzyme is involved in DNA methylation, which is the addition of methyl groups, consisting of one carbon atom and three hydrogen atoms (methylation), to DNA molecules. In particular, the enzyme helps add methyl groups to DNA building blocks (nucleotides) called cytosines.
DNA methylation is important in many cellular functions. These include determining whether the instructions in a particular segment of DNA are carried out or suppressed (gene silencing), regulating reactions involving proteins and fats (lipids), and controlling the processing of chemicals that relay signals in the nervous system (neurotransmitters). DNA (cytosine-5)-methyltransferase 1 is active in the adult nervous system. Although its specific function is not well understood, the enzyme may help regulate nerve cell (neuron) maturation and specialization (differentiation), the ability of neurons to migrate where needed and connect with each other, and neuron survival.
How are changes in the DNMT1 gene related to health conditions?
Where is the DNMT1 gene located?
Cytogenetic Location: 19p13.2
Molecular Location on chromosome 19: base pairs 10,133,345 to 10,195,079
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The DNMT1 gene is located on the short (p) arm of chromosome 19 at position 13.2.
More precisely, the DNMT1 gene is located from base pair 10,133,345 to base pair 10,195,079 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DNMT1?
You and your healthcare professional may find the following resources about DNMT1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DNMT1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DNMT1?
ataxia ; atom ; autosomal ; autosomal dominant ; cancer ; cell ; cytosine ; dementia ; differentiation ; DNA ; enzyme ; exon ; gene ; gene silencing ; hereditary ; inherited ; methyl ; methylation ; methyltransferase ; nerve cell ; nervous system ; neuron ; neuropathy ; neurotransmitters ; protein ; stomach ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.