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Reviewed November 2015
What is the official name of the DNM2 gene?
The official name of this gene is “dynamin 2.”
DNM2 is the gene's official symbol. The DNM2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DNM2 gene?
The DNM2 gene provides instructions for making a protein called dynamin 2. Dynamin 2 is present in cells throughout the body. It is involved in endocytosis, which is a process that brings substances into the cell. During endocytosis, the cell membrane folds around a substance (such as a protein) outside the cell to form a sac-like structure called a vesicle. The vesicle is drawn into the cell and is pinched off from the cell membrane. Dynamin 2 is thought to play a key role in altering the cell membrane to form these vesicles.
Dynamin 2 is also involved in the cell's structural framework (cytoskeleton). The protein interacts with multiple parts of the cytoskeleton, including tube-like structures called microtubules and proteins called actin, which organize into filaments to provide structure. These parts of the cytoskeleton are involved in movement of molecules within the cells, cell shape, cell mobility, and attachment of cells to one another.
How are changes in the DNM2 gene related to health conditions?
Where is the DNM2 gene located?
Cytogenetic Location: 19p13.2
Molecular Location on chromosome 19: base pairs 10,718,053 to 10,831,910
The DNM2 gene is located on the short (p) arm of chromosome 19 at position 13.2.
More precisely, the DNM2 gene is located from base pair 10,718,053 to base pair 10,831,910 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DNM2?
You and your healthcare professional may find the following resources about DNM2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DNM2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DNM2?
actin ; amino acid ; atrophy ; cell ; cell membrane ; cytoskeleton ; DNA ; endocytosis ; exon ; gene ; muscle cells ; peripheral ; peripheral nerves ; protein ; Schwann cells ; sensory cells ; vesicle ; wasting
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.