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Reviewed September 2013
What is the official name of the DNAJC5 gene?
The official name of this gene is “DnaJ (Hsp40) homolog, subfamily C, member 5.”
DNAJC5 is the gene's official symbol. The DNAJC5 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DNAJC5 gene?
The DNAJC5 provides instructions for making a protein called cysteine string protein alpha (CSPα). This protein is found in the brain, where it plays a role in the transmission of nerve impulses. CSPα helps sac-like structures called synaptic vesicles attach to nerve cells. Synaptic vesicles contain chemical messengers that transmit signals from one nerve cell to another.
Researchers suspect that CSPα may also help repair proteins that are involved in the transmission of nerve impulses by re-folding any that have the incorrect 3-dimensional shape.
Does the DNAJC5 gene share characteristics with other genes?
The DNAJC5 gene belongs to a family of genes called DNAJ (heat shock proteins, DNAJ (HSP40)).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the DNAJC5 gene related to health conditions?
Where is the DNAJC5 gene located?
Cytogenetic Location: 20q13.33
Molecular Location on chromosome 20: base pairs 63,895,101 to 63,936,030
The DNAJC5 gene is located on the long (q) arm of chromosome 20 at position 13.33.
More precisely, the DNAJC5 gene is located from base pair 63,895,101 to base pair 63,936,030 on chromosome 20.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DNAJC5?
You and your healthcare professional may find the following resources about DNAJC5 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DNAJC5 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DNAJC5?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.