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DISP1

DISP1

The information on this page was automatically extracted from online scientific databases.

What is the official name of the DISP1 gene?

The official name of this gene is “dispatched homolog 1 (Drosophila).”

DISP1 is the gene's official symbol. The DISP1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the DISP1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.

How are changes in the DISP1 gene related to health conditions?

Genetics Home Reference provides information about nonsyndromic holoprosencephaly, which is associated with changes in the DISP1 gene.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the DISP1 gene located?

Cytogenetic Location: 1q41

Molecular Location on chromosome 1: base pairs 222,815,088 to 223,005,994

The DISP1 gene is located on the long (q) arm of chromosome 1 at position 41.

The DISP1 gene is located on the long (q) arm of chromosome 1 at position 41.

More precisely, the DISP1 gene is located from base pair 222,815,088 to base pair 223,005,994 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about DISP1?

You and your healthcare professional may find the following resources about DISP1 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the DISP1 gene or gene products?

  • DISPA

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding DISP1?

cell ; cholesterol ; differentiation ; embryo ; embryonic ; extracellular ; gene ; homologs ; proliferation ; protein

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 21, 2014