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Reviewed May 2013
What is the official name of the DICER1 gene?
The official name of this gene is “dicer 1, ribonuclease type III.”
DICER1 is the gene's official symbol. The DICER1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DICER1 gene?
The DICER1 gene provides instructions for making a protein that plays a role in regulating the activity (expression) of other genes. The Dicer protein aids in the production of a molecule called microRNA (miRNA). MicroRNAs are short lengths of RNA, a chemical cousin of DNA. Dicer cuts (cleaves) precursor RNA molecules to produce miRNA.
MicroRNAs control gene expression by blocking the process of protein production. In the first step of making a protein from a gene, another type of RNA called messenger RNA (mRNA) is formed and acts as the blueprint for protein production. MicroRNAs attach to specific mRNA molecules and stop the process by which protein is made. Sometimes, miRNAs break down the mRNA, which also blocks protein production. Through this role in regulating the expression of genes, Dicer is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation).
How are changes in the DICER1 gene related to health conditions?
Where is the DICER1 gene located?
Cytogenetic Location: 14q32.13
Molecular Location on chromosome 14: base pairs 95,086,227 to 95,158,009
The DICER1 gene is located on the long (q) arm of chromosome 14 at position 32.13.
More precisely, the DICER1 gene is located from base pair 95,086,227 to base pair 95,158,009 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DICER1?
You and your healthcare professional may find the following resources about DICER1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DICER1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DICER1?
cell ; differentiation ; DNA ; expressed ; gene ; gene expression ; goiter ; helicase ; messenger RNA ; molecule ; motif ; mRNA ; nephroma ; precursor ; proliferation ; protein ; RNA ; syndrome ; thyroid ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.