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Reviewed August 2011
What is the official name of the DARS2 gene?
The official name of this gene is “aspartyl-tRNA synthetase 2, mitochondrial.”
DARS2 is the gene's official symbol. The DARS2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the DARS2 gene?
The DARS2 gene provides instructions for making an enzyme called mitochondrial aspartyl-tRNA synthetase. This enzyme is important in the production (synthesis) of proteins in cellular structures called mitochondria, the energy-producing centers in cells. While most protein synthesis occurs in the fluid surrounding the nucleus (cytoplasm), some proteins are synthesized in the mitochondria.
During protein synthesis, in either the mitochondria or the cytoplasm, a type of RNA called transfer RNA (tRNA) helps assemble protein building blocks (amino acids) into a chain that forms the protein. Each tRNA carries a specific amino acid to the growing chain. Enzymes called aminoacyl-tRNA synthetases, including mitochondrial aspartyl-tRNA synthetase, attach a particular amino acid to a specific tRNA. Mitochondrial aspartyl-tRNA synthetase attaches the amino acid aspartic acid to the correct tRNA, which helps ensure that aspartic acid is added at the proper place in the mitochondrial protein.
Does the DARS2 gene share characteristics with other genes?
The DARS2 gene belongs to a family of genes called aaRS (aminoacyl tRNA synthetases).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the DARS2 gene related to health conditions?
Where is the DARS2 gene located?
Cytogenetic Location: 1q25.1
Molecular Location on chromosome 1: base pairs 173,824,645 to 173,858,544
The DARS2 gene is located on the long (q) arm of chromosome 1 at position 25.1.
More precisely, the DARS2 gene is located from base pair 173,824,645 to base pair 173,858,544 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DARS2?
You and your healthcare professional may find the following resources about DARS2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the DARS2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DARS2?
acids ; amino acid ; aspartic acid ; brainstem ; cytoplasm ; enzyme ; gene ; lactate ; leukoencephalopathy ; ligase ; mitochondria ; mutation ; nucleus ; precursor ; protein ; RNA ; synthesis ; synthetases ; transfer RNA ; tRNA
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.