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Genetics Home Reference: your guide to understanding genetic conditions
http://ghr.nlm.nih.gov/     A service of the U.S. National Library of Medicine®

CYP4F22

The information on this page was automatically extracted from online scientific databases.

What is the official name of the CYP4F22 gene?

The official name of this gene is “cytochrome P450, family 4, subfamily F, polypeptide 22.”

CYP4F22 is the gene's official symbol. The CYP4F22 gene is also known by other names, listed below.

What is the normal function of the CYP4F22 gene?

From NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/126410):

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]

How are changes in the CYP4F22 gene related to health conditions?

Genetics Home Reference provides information about lamellar ichthyosis, which is associated with changes in the CYP4F22 gene.
OMIM.org (http://omim.org/), a catalog designed for genetics professionals and researchers, provides the following information about the CYP4F22 gene and its association with health conditions.
OMIM
Number
Title

Where is the CYP4F22 gene located?

Cytogenetic Location: 19p13.12

Molecular Location on chromosome 19: base pairs 15,508,483 to 15,552,316

The CYP4F22 gene is located on the short (p) arm of chromosome 19 at position 13.12.

The CYP4F22 gene is located on the short (p) arm of chromosome 19 at position 13.12.

More precisely, the CYP4F22 gene is located from base pair 15,508,483 to base pair 15,552,316 on chromosome 19.

See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.

Where can I find additional information about CYP4F22?

You and your healthcare professional may find the following resources about CYP4F22 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CYP4F22 gene or gene products?

  • ARCI5
  • INLNE
  • LI3

See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What glossary definitions help with understanding CYP4F22?

autosomal ; autosomal recessive ; cholesterol ; chromosome ; congenital ; cytochrome P450 ; differentiation ; enzyme ; epidermis ; erythroderma ; gene ; ichthyosiform ; ichthyosis ; metabolism ; recessive ; steroids ; synthesis

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (/glossary).

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Published: May 4, 2015