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The information on this page was automatically extracted from online scientific databases.

What is the official name of the CYP2C19 gene?

The official name of this gene is “cytochrome P450, family 2, subfamily C, polypeptide 19.”

CYP2C19 is the gene's official symbol. The CYP2C19 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the CYP2C19 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

From UniProt (CP2CJ_HUMAN)This link leads to a site outside Genetics Home Reference.:

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

NOTE: UniProt (CP2CJ_HUMAN)This link leads to a site outside Genetics Home Reference. suggests using caution when interpreting this information.

How are changes in the CYP2C19 gene related to health conditions?

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the CYP2C19 gene.
  • CYP2C19-related poor drug metabolism
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the CYP2C19 gene and its association with health conditions.

Where is the CYP2C19 gene located?

Cytogenetic Location: 10q24

Molecular Location on chromosome 10: base pairs 94,762,681 to 94,853,205

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The CYP2C19 gene is located on the long (q) arm of chromosome 10 at position 24.

The CYP2C19 gene is located on the long (q) arm of chromosome 10 at position 24.

More precisely, the CYP2C19 gene is located from base pair 94,762,681 to base pair 94,853,205 on chromosome 10.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about CYP2C19?

You and your healthcare professional may find the following resources about CYP2C19 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CYP2C19 gene or gene products?

  • CPCJ
  • CYP2C
  • CYPIIC17
  • CYPIIC19
  • P450C2C
  • P450IIC19

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CYP2C19?

chimera ; cholesterol ; chromosome ; clone ; cytochrome P450 ; endoplasmic reticulum ; gene ; metabolism ; polymorphism ; protein ; steroids ; synthesis ; xenobiotics

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: November 30, 2015