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Reviewed December 2015
What is the official name of the CYP2C19 gene?
The official name of this gene is “cytochrome P450 family 2 subfamily C member 19.”
CYP2C19 is the gene's official symbol. The CYP2C19 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CYP2C19 gene?
The CYP2C19 gene is a member of the cytochrome P450 gene family. Enzymes produced from cytochrome P450 genes are involved in the formation and breakdown (metabolism) of various molecules and chemicals within cells. The CYP2C19 gene provides instructions for making an enzyme that is found primarily in liver cells in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.
The CYP2C19 enzyme plays a role in the processing or metabolizing of at least 10 percent of commonly prescribed drugs, including a drug called clopidogrel (also known as Plavix). Clopidogrel is an antiplatelet drug, which means that it prevents blood cell fragments called platelets from sticking together (aggregating) and forming blood clots. The CYP2C19 enzyme converts clopidogrel to its active form, which is necessary for the drug to function in the body. The active drug then stops (inhibits) a receptor protein known as P2RY12 that is found on the surface of platelets. During clot formation, the P2RY12 receptor protein helps platelets cluster together to form a clot in order to seal off damaged blood vessels and prevent blood loss.
Does the CYP2C19 gene share characteristics with other genes?
The CYP2C19 gene belongs to a family of genes called CYP (cytochrome P450s).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CYP2C19 gene related to health conditions?
Where is the CYP2C19 gene located?
Cytogenetic Location: 10q24
Molecular Location on chromosome 10: base pairs 94,762,681 to 94,853,205
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The CYP2C19 gene is located on the long (q) arm of chromosome 10 at position 24.
More precisely, the CYP2C19 gene is located from base pair 94,762,681 to base pair 94,853,205 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CYP2C19?
You and your healthcare professional may find the following resources about CYP2C19 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CYP2C19 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CYP2C19?
antidepressants ; breakdown ; cell ; cytochrome P450 ; endoplasmic reticulum ; enzyme ; gene ; metabolism ; pharmacogenetics ; pharmacogenomics ; platelets ; polymorphism ; precursor ; protein ; proton ; receptor ; seizure ; stomach ; xenobiotic
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.