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Reviewed April 2014
What is the official name of the CYP19A1 gene?
The official name of this gene is “cytochrome P450, family 19, subfamily A, polypeptide 1.”
CYP19A1 is the gene's official symbol. The CYP19A1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CYP19A1 gene?
The CYP19A1 gene provides instructions for making an enzyme called aromatase. This enzyme converts a class of hormones called androgens, which are involved in male sexual development, to different forms of the female sex hormone estrogen.
In cells, aromatase is found in a structure called the endoplasmic reticulum, which is involved in protein production, processing, and transport. The activity (expression) of aromatase varies among different cell types depending on the cells' need for estrogen. In females, aromatase is most active in the ovaries, where it guides sexual development. In males, aromatase is most active in fat (adipose) tissue. In both males and females, estrogen plays a role in regulating bone growth and blood sugar levels. During fetal development, aromatase converts androgens to estrogens in the placenta, which is the link between the mother's blood supply and the fetus. This conversion in the placenta prevents androgens from directing sexual development in female fetuses. After birth, the conversion of androgens to estrogens takes place in multiple tissues.
Does the CYP19A1 gene share characteristics with other genes?
The CYP19A1 gene belongs to a family of genes called CYP (cytochrome P450s).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CYP19A1 gene related to health conditions?
Where is the CYP19A1 gene located?
Cytogenetic Location: 15q21.1
Molecular Location on chromosome 15: base pairs 51,208,056 to 51,338,597
The CYP19A1 gene is located on the long (q) arm of chromosome 15 at position 21.1.
More precisely, the CYP19A1 gene is located from base pair 51,208,056 to base pair 51,338,597 on chromosome 15.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CYP19A1?
You and your healthcare professional may find the following resources about CYP19A1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CYP19A1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CYP19A1?
androgens ; cell ; chromosome ; class ; cytochrome P450 ; deficiency ; DNA ; endoplasmic reticulum ; enzyme ; expressed ; fetus ; fusion gene ; gene ; gynecomastia ; hormone ; insulin ; insulin resistance ; inversion ; placenta ; protein ; rearrangement ; sex hormone ; short stature ; stature ; syndrome ; testosterone ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.