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Reviewed April 2014
What is the official name of the CTC1 gene?
The official name of this gene is “CTS telomere maintenance complex component 1.”
CTC1 is the gene's official symbol. The CTC1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CTC1 gene?
The CTC1 gene provides instructions for making a protein that plays an important role in structures known as telomeres, which are found at the ends of chromosomes. Telomeres are short, repetitive segments of DNA that help protect chromosomes from abnormally sticking together or breaking down (degrading). In most cells, telomeres become progressively shorter as the cell divides. After a certain number of cell divisions, the telomeres become so short that they trigger the cell to stop dividing or to self-destruct (undergo apoptosis).
The CTC1 protein works as part of a group of proteins known as the CST complex, which is involved in the maintenance of telomeres. This complex is part of the special machinery that some cells use to copy (replicate) telomeres so they do not become too short as cells divide. Studies suggest that the CTC1 protein may also have roles in DNA replication unrelated to telomeres, but these functions are not well understood.
How are changes in the CTC1 gene related to health conditions?
Genetics Home Reference provides information about dyskeratosis congenita, which is also associated with changes in the CTC1 gene.
Where is the CTC1 gene located?
Cytogenetic Location: 17p13.1
Molecular Location on chromosome 17: base pairs 8,224,820 to 8,248,094
The CTC1 gene is located on the short (p) arm of chromosome 17 at position 13.1.
More precisely, the CTC1 gene is located from base pair 8,224,820 to base pair 8,248,094 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CTC1?
You and your healthcare professional may find the following resources about CTC1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CTC1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CTC1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.