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Reviewed August 2010
What is the official name of the CRB1 gene?
The official name of this gene is “crumbs family member 1, photoreceptor morphogenesis associated.”
CRB1 is the gene's official symbol. The CRB1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CRB1 gene?
The CRB1 gene provides instructions for making a protein that plays an essential role in normal vision. This protein is found in the brain and the retina, which is the specialized tissue at the back of the eye that detects light and color.
In the retina, the CRB1 protein appears to be critical for the normal development of light-sensing cells called photoreceptors. Studies suggest that this protein is part of a group (complex) of proteins that help determine the structure and orientation of photoreceptors. The CRB1 protein may also be involved in forming connections between different types of cells in the retina.
How are changes in the CRB1 gene related to health conditions?
Genetics Home Reference provides information about retinitis pigmentosa, which is also associated with changes in the CRB1 gene.
Where is the CRB1 gene located?
Cytogenetic Location: 1q31.3
Molecular Location on chromosome 1: base pairs 197,201,461 to 197,478,454
The CRB1 gene is located on the long (q) arm of chromosome 1 at position 31.3.
More precisely, the CRB1 gene is located from base pair 197,201,461 to base pair 197,478,454 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CRB1?
You and your healthcare professional may find the following resources about CRB1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CRB1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CRB1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.