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Reviewed February 2008
What is the official name of the COMP gene?
The official name of this gene is “cartilage oligomeric matrix protein.”
COMP is the gene's official symbol. The COMP gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the COMP gene?
The COMP gene provides the instructions for making the COMP protein. This protein is found in the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells. Specifically, the COMP protein is located in the extracellular matrix surrounding the cells that make up ligaments and tendons, and near cartilage-forming cells (chondrocytes). Chondrocytes play an important role in bone formation (osteogenesis). In the bones of the spine, hips, and limbs, the process of osteogenesis starts with the formation of cartilage, which is then converted into bone.
The normal function of the COMP protein is not fully known. It is believed to play a role in cell growth and division (proliferation) and the self-destruction of cells (apoptosis), as well as in the regulation of cell movement and attachment. Research has also shown that the COMP protein binds strongly to calcium.
How are changes in the COMP gene related to health conditions?
Where is the COMP gene located?
Cytogenetic Location: 19p13.1
Molecular Location on chromosome 19: base pairs 18,782,773 to 18,791,305
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The COMP gene is located on the short (p) arm of chromosome 19 at position 13.1.
More precisely, the COMP gene is located from base pair 18,782,773 to base pair 18,791,305 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about COMP?
You and your healthcare professional may find the following resources about COMP helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the COMP gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding COMP?
acids ; amino acid ; apoptosis ; aspartic acid ; bone formation ; calcium ; cartilage ; cell ; chondrocyte ; deletion ; dysplasia ; endoplasmic reticulum ; extracellular ; extracellular matrix ; gene ; mutation ; osteogenesis ; proliferation ; protein ; short stature ; stature ; substitution
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.