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Reviewed August 2014
What is the official name of the COG5 gene?
The official name of this gene is “component of oligomeric golgi complex 5.”
COG5 is the gene's official symbol. The COG5 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the COG5 gene?
The COG5 gene provides instructions for making a protein called component of oligomeric Golgi complex 5 (COG5). As its name suggests, COG5 is one piece of a group of proteins known as the conserved oligomeric Golgi (COG) complex. This complex functions in the Golgi apparatus, which is a cell structure in which newly produced proteins are modified. One process that occurs in the Golgi apparatus is glycosylation, by which sugar molecules (oligosaccharides) are attached to proteins and fats. Glycosylation modifies proteins so they can perform a wider variety of functions.
The COG complex takes part in the transport of proteins, including the enzymes that perform glycosylation, within the Golgi apparatus. COG is specifically involved in retrograde transport, which moves proteins backward through the Golgi apparatus. Retrograde transport is important for recycling Golgi proteins and ensuring that they are in the correct location in the structure, which is key to proper glycosylation. The proteins are transported in sac-like structures called vesicles that attach to the Golgi membrane and release the contents into the Golgi apparatus. The COG complex controls the attachment (tethering) of the vesicles to the Golgi membrane.
How are changes in the COG5 gene related to health conditions?
Where is the COG5 gene located?
Cytogenetic Location: 7q31
Molecular Location on chromosome 7: base pairs 107,201,744 to 107,564,514
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The COG5 gene is located on the long (q) arm of chromosome 7 at position 31.
More precisely, the COG5 gene is located from base pair 107,201,744 to base pair 107,564,514 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about COG5?
You and your healthcare professional may find the following resources about COG5 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the COG5 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding COG5?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.