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Reviewed February 2014
What is the official name of the CDT1 gene?
The official name of this gene is “chromatin licensing and DNA replication factor 1.”
CDT1 is the gene's official symbol. The CDT1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CDT1 gene?
The CDT1 gene provides instructions for making a protein that is important in the copying of a cell's DNA before the cell divides (a process known as DNA replication). The protein produced from this gene is one of a group of proteins known as the pre-replication complex. In a multi-step process, the components of this complex attach (bind) to certain regions of DNA known as origins of replication (or origins), where the process of DNA copying begins. When the pre-replication complex is attached to the origin, replication is able to begin at that location. This tightly controlled process, called replication licensing, helps ensure that DNA replication occurs only once per cell division and is required for cells to divide.
How are changes in the CDT1 gene related to health conditions?
Where is the CDT1 gene located?
Cytogenetic Location: 16q24.3
Molecular Location on chromosome 16: base pairs 88,803,778 to 88,809,258
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The CDT1 gene is located on the long (q) arm of chromosome 16 at position 24.3.
More precisely, the CDT1 gene is located from base pair 88,803,778 to base pair 88,809,258 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CDT1?
You and your healthcare professional may find the following resources about CDT1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CDT1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CDT1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.