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Reviewed June 2015
What is the official name of the CDKN1C gene?
The official name of this gene is “cyclin-dependent kinase inhibitor 1C (p57, Kip2).”
CDKN1C is the gene's official symbol. The CDKN1C gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CDKN1C gene?
The CDKN1C gene provides instructions for making a protein that helps regulate growth. This protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. It also is involved in controlling growth before birth, preventing the developing fetus from becoming too large.
People inherit one copy of most genes from their mother and one copy from their father. Both copies are typically active, or "turned on," in cells. However, the activity of the CDKN1C gene depends on which parent it was inherited from. In most tissues, the copy of the gene inherited from a person's mother (the maternally inherited copy) has much higher activity than the copy inherited from the father (the paternally inherited copy). This sort of parent-specific difference in gene activation is caused by a phenomenon called genomic imprinting.
CDKN1C is part of a cluster of genes on the short (p) arm of chromosome 11 that undergo genomic imprinting. A nearby region of DNA known as imprinting center 2 (IC2) or KvDMR controls the parent-specific genomic imprinting of CDKN1C and several other genes thought to help regulate growth. The IC2 region undergoes a process called methylation, which is a chemical reaction that attaches small molecules called methyl groups to certain segments of DNA. Methylation, which occurs during the formation of an egg or sperm cell, is a way of marking or "stamping" the parent of origin. The IC2 region is normally methylated only on the maternally inherited copy of chromosome 11.
How are changes in the CDKN1C gene related to health conditions?
Where is the CDKN1C gene located?
Cytogenetic Location: 11p15.5
Molecular Location on chromosome 11: base pairs 2,883,217 to 2,885,815
The CDKN1C gene is located on the short (p) arm of chromosome 11 at position 15.5.
More precisely, the CDKN1C gene is located from base pair 2,883,217 to base pair 2,885,815 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CDKN1C?
You and your healthcare professional may find the following resources about CDKN1C helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CDKN1C gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CDKN1C?
acids ; cell ; chromosome ; DNA ; domain ; dysplasia ; egg ; epigenetic ; fetus ; gene ; hypoplasia ; imprinting ; inherit ; inherited ; kinase ; methyl ; methylation ; mutation ; proliferating ; protein ; sperm ; syndrome ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.