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Reviewed August 2013
What is the official name of the CDKN1B gene?
The official name of this gene is “cyclin-dependent kinase inhibitor 1B (p27, Kip1).”
CDKN1B is the gene's official symbol. The CDKN1B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CDKN1B gene?
The CDKN1B gene provides instructions for making a protein called p27. This protein is found in cells and tissues throughout the body. Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division. It helps regulate the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion. Specifically, p27 normally blocks cells from entering the phase of the cell cycle when DNA is copied (replicated) in preparation for cell division. By blocking cell cycle progression, p27 prevents cells from dividing too quickly or at the wrong time. Based on this function, p27 is described as a tumor suppressor protein. Studies suggest that p27 is also involved in controlling cell differentiation, which is the process by which cells mature to carry out specific functions.
Because p27 plays such a key role in controlling cell division, its activity is tightly regulated. Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. Researchers believe that p27 may have other functions in the cytoplasm, but these functions have not been well described.
How are changes in the CDKN1B gene related to health conditions?
Where is the CDKN1B gene located?
Cytogenetic Location: 12p13.1-p12
Molecular Location on chromosome 12: base pairs 12,717,270 to 12,722,383
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The CDKN1B gene is located on the short (p) arm of chromosome 12 between positions 13.1 and 12.
More precisely, the CDKN1B gene is located from base pair 12,717,270 to base pair 12,722,383 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CDKN1B?
You and your healthcare professional may find the following resources about CDKN1B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CDKN1B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CDKN1B?
acids ; cancer ; cell ; cell cycle ; cell division ; cytoplasm ; differentiation ; DNA ; gene ; hormone ; inherited ; kinase ; neoplasia ; nucleus ; parathyroid ; pituitary gland ; prognosis ; progression ; protein ; sporadic ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.