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Reviewed August 2012
What is the official name of the CDC73 gene?
The official name of this gene is “cell division cycle 73.”
CDC73 is the gene's official symbol. The CDC73 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CDC73 gene?
The CDC73 gene (also known as the HRPT2 gene) provides instructions for making a protein called parafibromin. This protein is primarily found in the nucleus of cells and is likely involved in regulating gene transcription, which is the first step in protein production. Parafibromin is also thought to play a role in cell growth and division (proliferation), either promoting or inhibiting cell proliferation depending on signals within the cell. When parafibromin is found outside the nucleus, it appears to be involved in the organization of the cell's structural framework (the cytoskeleton).
How are changes in the CDC73 gene related to health conditions?
Where is the CDC73 gene located?
Cytogenetic Location: 1q25
Molecular Location on chromosome 1: base pairs 193,121,957 to 193,254,814
The CDC73 gene is located on the long (q) arm of chromosome 1 at position 25.
More precisely, the CDC73 gene is located from base pair 193,121,957 to base pair 193,254,814 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CDC73?
You and your healthcare professional may find the following resources about CDC73 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CDC73 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CDC73?
calcium ; cancer ; cell ; cell division ; cell division cycle ; cell proliferation ; cytoskeleton ; familial ; gene ; gene transcription ; hormone ; hypercalcemia ; hyperparathyroidism ; hypertension ; inherited ; kidney ; kidney stones ; nucleus ; osteoporosis ; parathyroid ; proliferation ; protein ; RNA ; RNA polymerase ; syndrome ; transcription ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.