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The information on this page was automatically extracted from online scientific databases.

What is the official name of the CD28 gene?

The official name of this gene is “CD28 molecule.”

CD28 is the gene's official symbol. The CD28 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the CD28 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

From UniProt (CD28_HUMAN)This link leads to a site outside Genetics Home Reference.:

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

How are changes in the CD28 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the CD28 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the CD28 gene and its association with health conditions.

Where is the CD28 gene located?

Cytogenetic Location: 2q33

Molecular Location on chromosome 2: base pairs 203,706,475 to 203,738,912

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The CD28 gene is located on the long (q) arm of chromosome 2 at position 33.

The CD28 gene is located on the long (q) arm of chromosome 2 at position 33.

More precisely, the CD28 gene is located from base pair 203,706,475 to base pair 203,738,912 on chromosome 2.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about CD28?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CD28 gene or gene products?

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CD28?

cell ; cell proliferation ; cytokine ; gene ; isoforms ; proliferation ; protein ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: February 8, 2016