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CD19

CD19

The information on this page was automatically extracted from online scientific databases.

What is the official name of the CD19 gene?

The official name of this gene is “CD19 molecule.”

CD19 is the gene's official symbol. The CD19 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the CD19 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

How are changes in the CD19 gene related to health conditions?

Genetics Home Reference provides information about common variable immune deficiency, which is associated with changes in the CD19 gene.
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the CD19 gene's known or predicted involvement in human disease.

Immunodeficiency, common variable, 3 (CVID3): A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the CD19 gene.
  • Common variable immunodeficiency 2
  • Common variable immunodeficiency 3
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the CD19 gene and its association with health conditions.
OMIM
Number
Title

Where is the CD19 gene located?

Cytogenetic Location: 16p11.2

Molecular Location on chromosome 16: base pairs 28,931,760 to 28,939,346

The CD19 gene is located on the short (p) arm of chromosome 16 at position 11.2.

The CD19 gene is located on the short (p) arm of chromosome 16 at position 11.2.

More precisely, the CD19 gene is located from base pair 28,931,760 to base pair 28,939,346 on chromosome 16.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about CD19?

You and your healthcare professional may find the following resources about CD19 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CD19 gene or gene products?

  • B4
  • CVID3

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CD19?

antibody ; antigens ; B-cells ; B-lymphocytes ; cell ; deficiency ; differentiation ; gene ; immunodeficiency ; molecule ; mutation ; proliferate ; receptor ; secretion

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: November 24, 2014