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CCR5

CCR5

The information on this page was automatically extracted from online scientific databases.

What is the official name of the CCR5 gene?

The official name of this gene is “chemokine (C-C motif) receptor 5 (gene/pseudogene).”

CCR5 is the gene's official symbol. The CCR5 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the CCR5 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

How are changes in the CCR5 gene related to health conditions?

Genetics Home Reference provides information about type 1 diabetes, which is associated with changes in the CCR5 gene.
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the CCR5 gene's known or predicted involvement in human disease.

Diabetes mellitus, insulin-dependent, 22 (IDDM22): A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.[1]This link leads to a site outside Genetics Home Reference. Disease susceptibility is associated with variations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the CCR5 gene.
  • Diabetes mellitus, insulin-dependent, 22[1]This link leads to a site outside Genetics Home Reference.
  • Hepatitis c virus, susceptibility to[2]This link leads to a site outside Genetics Home Reference.
  • West nile virus, susceptibility to[3]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]
[2]
[3]

Where is the CCR5 gene located?

Cytogenetic Location: 3p21.31

Molecular Location on chromosome 3: base pairs 46,370,141 to 46,376,205

The CCR5 gene is located on the short (p) arm of chromosome 3 at position 21.31.

The CCR5 gene is located on the short (p) arm of chromosome 3 at position 21.31.

More precisely, the CCR5 gene is located from base pair 46,370,141 to base pair 46,376,205 on chromosome 3.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about CCR5?

You and your healthcare professional may find the following resources about CCR5 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the CCR5 gene or gene products?

  • CCCKR5
  • CC-CKR-5
  • CCR-5
  • CD195
  • CKR5
  • CKR-5
  • CMKBR5
  • IDDM22

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding CCR5?

calcium ; cell ; diabetes ; diabetes mellitus ; differentiation ; expressed ; gene ; glucose ; hepatitis ; HIV ; homeostasis ; hyperglycemia ; infection ; insulin ; intracellular ; lineage ; macrophage ; monocyte ; polydipsia ; polyphagia ; polyuria ; proliferation ; protein ; receptor ; susceptibility ; transcript ; transmembrane ; virus

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 28, 2014