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Reviewed April 2010
What is the official name of the CATSPER1 gene?
The official name of this gene is “cation channel, sperm associated 1.”
CATSPER1 is the gene's official symbol. The CATSPER1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CATSPER1 gene?
The CATSPER1 gene provides instructions for producing a protein that is found in the tail (flagellum) of sperm cells. The CATSPER1 protein plays a role in sperm cell movement (motility) and is required for sperm cells to push through the outside membrane of the egg cell during fertilization. The CATSPER1 protein is embedded in the membrane of sperm cells and is necessary for positively charged calcium atoms (calcium cations) to enter the cell. Calcium cations are required for a type of sperm motility called hyperactivation. Hyperactivation is characterized by vigorous movements of the sperm tail, which are necessary for the sperm to push through the membrane of the egg cell during fertilization.
Does the CATSPER1 gene share characteristics with other genes?
The CATSPER1 gene belongs to a family of genes called CATSPER (CatSper channels).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the CATSPER1 gene related to health conditions?
Where is the CATSPER1 gene located?
Cytogenetic Location: 11q12.1
Molecular Location on chromosome 11: base pairs 66,016,752 to 66,026,519
The CATSPER1 gene is located on the long (q) arm of chromosome 11 at position 12.1.
More precisely, the CATSPER1 gene is located from base pair 66,016,752 to base pair 66,026,519 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CATSPER1?
You and your healthcare professional may find the following resources about CATSPER1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CATSPER1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CATSPER1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (4 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.