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Reviewed March 2013
What is the official name of the CARD14 gene?
The official name of this gene is “caspase recruitment domain family member 14.”
CARD14 is the gene's official symbol. The CARD14 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the CARD14 gene?
The CARD14 gene provides instructions for making a protein that turns on (activates) a group of interacting proteins known as nuclear factor-kappa-B (NF-κB). The NF-κB protein complex regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. It also protects cells from certain signals that would otherwise cause them to self-destruct (undergo apoptosis).
The CARD14 protein is found in many of the body's tissues, but it is particularly abundant in the skin. NF-κB signaling appears to play important roles in regulating inflammatory reactions in the skin and in promoting the survival of skin cells.
How are changes in the CARD14 gene related to health conditions?
Genetics Home Reference provides information about psoriatic arthritis, which is also associated with changes in the CARD14 gene.
Where is the CARD14 gene located?
Cytogenetic Location: 17q25
Molecular Location on chromosome 17: base pairs 80,169,992 to 80,209,331
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The CARD14 gene is located on the long (q) arm of chromosome 17 at position 25.
More precisely, the CARD14 gene is located from base pair 80,169,992 to base pair 80,209,331 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about CARD14?
You and your healthcare professional may find the following resources about CARD14 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the CARD14 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding CARD14?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.