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Reviewed March 2013
What is the official name of the BDNF gene?
The official name of this gene is “brain-derived neurotrophic factor.”
BDNF is the gene's official symbol. The BDNF gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the BDNF gene?
The BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called synaptic plasticity. The BDNF protein helps regulate synaptic plasticity, which is important for learning and memory.
The BDNF protein is found in regions of the brain that control eating, drinking, and body weight; the protein likely contributes to the management of these functions.
Does the BDNF gene share characteristics with other genes?
The BDNF gene belongs to a family of genes called endogenous ligands (endogenous ligands).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the BDNF gene related to health conditions?
Where is the BDNF gene located?
Cytogenetic Location: 11p13
Molecular Location on chromosome 11: base pairs 27,654,892 to 27,722,057
The BDNF gene is located on the short (p) arm of chromosome 11 at position 13.
More precisely, the BDNF gene is located from base pair 27,654,892 to base pair 27,722,057 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about BDNF?
You and your healthcare professional may find the following resources about BDNF helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the BDNF gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding BDNF?
amino acid ; anxiety ; autism ; bipolar disorder ; cell ; chromosome ; differentiation ; disability ; gene ; mental retardation ; methionine ; neurological ; plasticity ; polymorphism ; protein ; schizophrenia ; syndrome ; tumor ; valine ; Wilms tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.