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Reviewed November 2008
What is the official name of the ATN1 gene?
The official name of this gene is “atrophin 1.”
ATN1 is the gene's official symbol. The ATN1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ATN1 gene?
The ATN1 gene provides instructions for making a protein called atrophin 1. Although the exact function of this protein is unknown, it appears to play an important role in nerve cells (neurons) in many areas of the brain. Based on studies in other animals, researchers speculate that atrophin 1 may act as a transcriptional co-repressor. A transcriptional co-repressor is a protein that interacts with other DNA-binding proteins to suppress the activity of certain genes, although it cannot attach (bind) to DNA by itself.
One region of the ATN1 gene contains a particular DNA segment known as a CAG trinucleotide repeat. This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row. In most people, the number of CAG repeats in the ATN1 gene ranges from 6 to 35.
How are changes in the ATN1 gene related to health conditions?
Where is the ATN1 gene located?
Cytogenetic Location: 12p13.31
Molecular Location on chromosome 12: base pairs 6,924,462 to 6,942,320
The ATN1 gene is located on the short (p) arm of chromosome 12 at position 13.31.
More precisely, the ATN1 gene is located from base pair 6,924,462 to base pair 6,942,320 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ATN1?
You and your healthcare professional may find the following resources about ATN1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ATN1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ATN1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.