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Reviewed April 2011
What is the official name of the ASPM gene?
The official name of this gene is “abnormal spindle microtubule assembly.”
ASPM is the gene's official symbol. The ASPM gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ASPM gene?
The ASPM gene provides instructions for making a protein that is involved in cell division. This protein is found in cells and tissues throughout the body; however, it appears to be particularly important for the division of cells in the developing brain. Studies suggest that the ASPM protein helps maintain the orderly division of early brain cells called neural progenitor cells, which ultimately give rise to mature nerve cells (neurons). By promoting the division of neural progenitor cells during early brain development, the ASPM protein helps determine the total number of neurons and the overall size of the brain.
How are changes in the ASPM gene related to health conditions?
Genetics Home Reference provides information about age-related macular degeneration, which is also associated with changes in the ASPM gene.
Where is the ASPM gene located?
Cytogenetic Location: 1q31
Molecular Location on chromosome 1: base pairs 197,084,126 to 197,146,693
The ASPM gene is located on the long (q) arm of chromosome 1 at position 31.
More precisely, the ASPM gene is located from base pair 197,084,126 to base pair 197,146,693 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ASPM?
You and your healthcare professional may find the following resources about ASPM helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ASPM gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ASPM?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.