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Reviewed May 2013
What is the official name of the ARID1A gene?
The official name of this gene is “AT rich interactive domain 1A (SWI-like).”
ARID1A is the gene's official symbol. The ARID1A gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ARID1A gene?
The ARID1A gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.
Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells. The ARID1A protein and other SWI/SNF subunits are thought to act as tumor suppressors, which keep cells from growing and dividing too rapidly or in an uncontrolled way.
The ARID1A subunit is able to attach (bind) to DNA and is thought to help target SWI/SNF complexes to the chromatin location that needs to be remodeled.
How are changes in the ARID1A gene related to health conditions?
Where is the ARID1A gene located?
Cytogenetic Location: 1p35.3
Molecular Location on chromosome 1: base pairs 26,696,030 to 26,782,109
The ARID1A gene is located on the short (p) arm of chromosome 1 at position 35.3.
More precisely, the ARID1A gene is located from base pair 26,696,030 to base pair 26,782,109 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ARID1A?
You and your healthcare professional may find the following resources about ARID1A helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ARID1A gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ARID1A?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.