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Reviewed October 2006
What is the official name of the ARG1 gene?
The official name of this gene is “arginase 1.”
ARG1 is the gene's official symbol. The ARG1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ARG1 gene?
The ARG1 gene provides instructions for producing the enzyme arginase. This enzyme participates in the urea cycle, a series of reactions that occurs in liver cells. The urea cycle processes excess nitrogen, which is generated when proteins and their building blocks (amino acids) are used by the body. Through the urea cycle, excess nitrogen is made into a compound called urea that is excreted by the kidneys. Excreting the excess nitrogen prevents it from accumulating in the form of ammonia, which is toxic.
Arginase controls the last step of the urea cycle, a reaction in which nitrogen is removed from the amino acid arginine and processed into urea for excretion from the body. A compound called ornithine is also produced in this reaction; it is needed for the urea cycle to repeat.
How are changes in the ARG1 gene related to health conditions?
Where is the ARG1 gene located?
Cytogenetic Location: 6q23
Molecular Location on chromosome 6: base pairs 131,573,202 to 131,584,331
The ARG1 gene is located on the long (q) arm of chromosome 6 at position 23.
More precisely, the ARG1 gene is located from base pair 131,573,202 to base pair 131,584,331 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ARG1?
You and your healthcare professional may find the following resources about ARG1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ARG1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ARG1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.