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Reviewed November 2012
What is the official name of the APOA1 gene?
The official name of this gene is “apolipoprotein A-I.”
APOA1 is the gene's official symbol. The APOA1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the APOA1 gene?
The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body.
ApoA-I attaches to cell membranes and promotes the movement of cholesterol and phospholipids from inside the cell to the outer surface. Once outside the cell, these substances combine with apoA-I to form HDL. ApoA-I also triggers a reaction called cholesterol esterification that converts cholesterol to a form that can be fully integrated into HDL and transported through the bloodstream.
HDL is often referred to as "good cholesterol" because high levels of this substance reduce the chances of developing heart and blood vessel (cardiovascular) disease. The process of removing excess cholesterol from cells is extremely important for balancing cholesterol levels and maintaining cardiovascular health.
How are changes in the APOA1 gene related to health conditions?
Where is the APOA1 gene located?
Cytogenetic Location: 11q23-q24
Molecular Location on chromosome 11: base pairs 116,835,750 to 116,837,646
The APOA1 gene is located on the long (q) arm of chromosome 11 between positions 23 and 24.
More precisely, the APOA1 gene is located from base pair 116,835,750 to base pair 116,837,646 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about APOA1?
You and your healthcare professional may find the following resources about APOA1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the APOA1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding APOA1?
amyloid ; amyloidosis ; apolipoprotein ; apolipoprotein A-I ; cardiomyopathy ; cardiovascular ; cell ; cholesterol ; chronic ; deficiency ; familial ; gene ; HDL ; inherited ; kidney ; lipoprotein ; molecule ; mutation ; phospholipids ; protein ; viscera
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.