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APCDD1

APCDD1

The information on this page was automatically extracted from online scientific databases.

What is the official name of the APCDD1 gene?

The official name of this gene is “adenomatosis polyposis coli down-regulated 1.”

APCDD1 is the gene's official symbol. The APCDD1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the APCDD1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.

How are changes in the APCDD1 gene related to health conditions?

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the APCDD1 gene.
  • Hypotrichosis simplex
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the APCDD1 gene and its association with health conditions.
OMIM
Number
Title

Where is the APCDD1 gene located?

Cytogenetic Location: 18p11.22

Molecular Location on chromosome 18: base pairs 10,454,627 to 10,488,700

The APCDD1 gene is located on the short (p) arm of chromosome 18 at position 11.22.

The APCDD1 gene is located on the short (p) arm of chromosome 18 at position 11.22.

More precisely, the APCDD1 gene is located from base pair 10,454,627 to base pair 10,488,700 on chromosome 18.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about APCDD1?

You and your healthcare professional may find the following resources about APCDD1 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the APCDD1 gene or gene products?

  • B7323
  • DRAPC1
  • FP7019
  • HHS
  • HTS
  • HYPT1

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding APCDD1?

cell ; colorectal ; gene ; hereditary ; hypotrichosis ; locus

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: December 22, 2014